ASTM E857-2005e1 用鸟类进行亚极性饮食毒性试验的标准实施规程

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【英文标准名称】:StandardPracticeforConductingSubacuteDietaryToxicityTestswithAvianSpecies
【原文标准名称】:用鸟类进行亚极性饮食毒性试验的标准实施规程
【标准号】:ASTME857-2005e1
【标准状态】:现行
【国别】:
【发布日期】:2005
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:E47.02
【标准类型】:(Practice)
【标准水平】:()
【中文主题词】:危险物质;农药;污染控制;资源取回;试验;有毒物质;毒性;废弃物处置
【英文主题词】:
【摘要】:Thispracticeprovidesameansofmeasuringthesusceptibilityofanavianspeciestoatestsubstanceinitsdietundercontrolledconditions.TheLC50obtainedinthistestisaconditionalmeasureofsubacutetoxicitybecauseconsumptionisvoluntary,andbecausethedietaryroutemayintroducemetabolictransformationsofthetestsubstancethatmightbeabsentinotherexposuretechniques.Useofthispracticecontributestotheevaluationofthehazardsofchemicalstobirdsbecauseexposureisanalogoustomostfieldexposures,thatis,throughdietaryintake.Theuseofthispracticeallowsforobservationofsignsoftoxicityinadditiontomortality.Thedose-responsecurveprovidesadditionalinformationabouttheresponseofbirdstoatestsubstance.Thispracticecanbeusedtostudytheeffectsoftestsubstancesincombinationinordertosimulatesituationswherebirdsmaybeexposedtomorethanonesubstancesimultaneously(1).3Thispracticeprovidesonebasisfordecidingwhetheradditionaltoxicitytestingshouldbeconductedwithbirds.1.1Thispracticedescribesaprocedurefordeterminingthesubacutedietarytoxicityofatestsubstanceadministeredtobirdsintheirdailydiet.TheLC50valuetimetomortalityandslopeofthedoseresponsecurvemayalsobederived.1.2Thispracticeisapplicabletosubstancesthatcanbemixeduniformlyintothediet.1.3Thispracticeisintendedprimarilytobeusedwiththeyoungofthefollowingspecies:northernbobwhite(Colinusvirginianus),Japanesequail(Coturnixjaponica),mallard(Anasplatyrhynchos),andring-neckedpheasant(Phasianuscolchicus).Otherspeciesoragegroups,forexample,withwild-trappedbirds,maybeusedwithappropriatehusbandrymodificationstothepractice.1.4Thisstandardisusedroutinelytoaddressavianregulatorytestingrequirements.Modificationstotheproceduresdescribedinthisstandardhavebeenproposedandarebeingevaluatedtobetteraddresstheneedsofthelatestriskassessmentprocedures.Specifically,thelatestprocedurescallforindividualbirdfeedconsumptionmeasurementssothatamoreprecisedosecanbedetermined.Whilesuchproceduresmayreplaceproceduresdescribedinthecurrentstandard,thereisnocertaintythatthenewestprocedureswillworkasanticipated,andthecompletionofvalidationisnotcomplete.Therefore,thecurrentguidelinehasutilitypriortovalidationandacceptanceofamodifiedstandard.Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.ForspecificprecautionarystatementsseeSection6.
【中国标准分类号】:C53;B25;B4
【国际标准分类号】:
【页数】:5P.;A4
【正文语种】: